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Introduction:
Dengue virus, belonging to the Flava virus group of viruses, is one of the most significant mosquito-borne diseases in the world in terms of morbidity and mortality. Transmitted principally by the mosquito types Aedes aegypti and Aedes albopictus, the virus is found commonly throughout the tropic and subtropic regions of the world. There are four known serotypes of dengue. Symptoms of dengue fever include high fever, headache, muscle pain, and skin rash. The complications often associated with this infection are dengue hemorrhagic fever or dengue shock syndrome. The immune responses to this virus include the production of IgM antibodies by the 5th day of symptoms, which remain in the circulatory system for 30-60 days. IgG antibodies appear by the 14th day of infection and persist for life. A secondary infection often results in high fever and, in many cases, initiates hemorrhagic events and circulatory failure. A secondary infection also induces an IgM antibody response after 20 days of infection and IgG antibodies to rise within 1-2 days after the onset of symptoms. Therefore, patients with secondary infections will have a positive IgG result, usually with a positive IgM result as well. Thus, the use of a reliable and sensitive rapid serological test that can simultaneously detect the presence of anti-dengue IgG and IgM antibodies is of great clinical utility.
The Intended use of Dengue IgG & IgM Rapid Test:
Dengue IgG & IgM Rapid Test is a qualitative test for the detection of IgM and IgG antibodies to dengue virus in human whole blood, serum, or plasma. This test is for in-vitro diagnostic use only.
Principle of Dengue IgG & IgM Rapid Test:
Whole blood, serum, or plasma specimens may be used with this test. When a specimen is added to the test, IgG and IgM antibodies in the specimen react with gold particles coated with dengue envelope proteins. As this specimen and particle mixture migrates along the length of the test, the anti-dengue IgG or IgM antibody particle complex is captured to form a red line in the test region. The intensity of the lines will vary depending upon the amount of antibodies present in the specimen. The appearance of any color in the test region should be considered positive for IgG or IgM antibody. To serve as a procedural control, a red-colored line in the control region will always appear if the test procedure is performed properly and the test reagents of the control line are working.
Introduction:
Dengue virus, belonging to the Flava virus group of viruses, is one of the most significant mosquito-borne diseases in the world in terms of morbidity and mortality. Transmitted principally by the mosquito types Aedes aegypti and Aedes albopictus, the virus is found commonly throughout the tropic and subtropic regions of the world. There are four known serotypes of dengue. Symptoms of dengue fever include high fever, headache, muscle pain, and skin rash. The complications often associated with this infection are dengue hemorrhagic fever or dengue shock syndrome. The immune responses to this virus include the production of IgM antibodies by the 5th day of symptoms, which remain in the circulatory system for 30-60 days. IgG antibodies appear by the 14th day of infection and persist for life. A secondary infection often results in high fever and, in many cases, initiates hemorrhagic events and circulatory failure. A secondary infection also induces an IgM antibody response after 20 days of infection and IgG antibodies to rise within 1-2 days after the onset of symptoms. Therefore, patients with secondary infections will have a positive IgG result, usually with a positive IgM result as well. Thus, the use of a reliable and sensitive rapid serological test that can simultaneously detect the presence of anti-dengue IgG and IgM antibodies is of great clinical utility.
The Intended use of Dengue IgG & IgM Rapid Test:
Dengue IgG & IgM Rapid Test is a qualitative test for the detection of IgM and IgG antibodies to dengue virus in human whole blood, serum, or plasma. This test is for in-vitro diagnostic use only.
Principle of Dengue IgG & IgM Rapid Test:
Whole blood, serum, or plasma specimens may be used with this test. When a specimen is added to the test, IgG and IgM antibodies in the specimen react with gold particles coated with dengue envelope proteins. As this specimen and particle mixture migrates along the length of the test, the anti-dengue IgG or IgM antibody particle complex is captured to form a red line in the test region. The intensity of the lines will vary depending upon the amount of antibodies present in the specimen. The appearance of any color in the test region should be considered positive for IgG or IgM antibody. To serve as a procedural control, a red-colored line in the control region will always appear if the test procedure is performed properly and the test reagents of the control line are working.