CORE GROUP,

Our One Step Cardiac Troponin I Test Device is intended for the qualitative determination of cardiac troponin I in human whole blood, plasma or serum. Measurement of troponin I values is useful in the evaluation of acute myocardial infarction (AMI).
Cardiac Troponin I (cTnI) is a cardiac muscle protein with a molecular weight of 22.5 kilodaltons. Together with troponin T (TnT) and troponin C (TnC), cTnI forms a troponin complex in the heart to play a fundamental role in the transmission of intracellular calcium signal actin-myosin interaction. Although troponin I is also found in skeletal muscle, cardiac troponin I (cTnI) has additional amino acid residues on its N-terminal which distinguishes it from its skeletal muscle form making cTnI a specific marker for indicating cardiac infarction. cTnI is released rapidly into blood stream soon after the onset of acute myocardial infarction (AMI). Its release pattern is similar to CK-MB (4-6 hours after the onset of AMI). However, CK-MB level returns to normal after 48-72 hours, when levels of cTnI remain elevated for up to 6-10 days. The level of cTnI is below 0.06ng/ml in average healthy people and is also not detected in the patients with skeletal muscle injury. Therefore, cTnI is a specific marker for diagnosis of AMI patients. The level of cTnI may reach 100-1300ng/ml in some AMI patients.

The Detection of Cardiac Troponin I